B12 and Methylation


What is Methyl-B12 (MB12)?

B12 (cobalamin) is a vitamin “family” with five unique family members that each do different things.  Out of the B12 family, only methyl-B12 has the ability to activate the methionine/homocysteine biochemical pathway directly which results in more “fuel” to the brain.

MB12 works with folic acid to make all the cells in the body.  It plays a key role in METHYLATION.  Methylation makes ALL of the cells in our body.  It is the process of adding genetic material to cells.  After conception, the cells in the womb that will later become the fetus are DEMETHYLATED.  The process of development depends on methylation.

Increasing evidence is revealing the role of methylation in the interaction of environmental factors with genetic expression. Differences in maternal care during the first 6 days of life in a mammal can cause different methylation patterns in some genes.  Methylation has also been shown to impact inflammation after a child leaves the womb.

Methylation is responsible for:

  • RNA and DNA (genetic material responsible for every function in the body)
  • Immune system regulation
  • Detoxification of heavy metals and other harmful substances
  • Making GLUTATHIONE (the body’s main detoxification enzyme responsible for removing mercury, lead, cadmium, arsenic, nickel, tin, aluminum and antimony)
  • Production and function of proteins
  • Regulating inflammation


What connects MB12, methylation, glutathione and ASD?

Short answer:
   Dr. S. Jill James (who has recently received a NIH – National Institute of Health – grant for her research) has shown that children with ASD have impaired methylation and decreased levels of glutathione.  Supporting and/or repairing the underlying impairment and deficiency translates into INCREASED LANGUAGE, SOCIAL AND COGNITIVE  DEVELOPMENT.

Long answer: 
Dr. S. Jill James has also shown that children with ASD have 80% less glutathione in their cells and that 90% of children have defects in their methylation.  This means that children with autism cannot effectively fuel the brain and detoxify heavy metals and other harmful substances from their system.
The brain is the only part of the body that has depends entirely on MB12 to detoxify.  As the the brain is over-burdened with toxic substances, the “wheels” of methylation slow, severely impacting development.
MB12 works closely with folic acid. A precursor folic acid molecule must interact with the enzyme MTHFR (methylenetetrahydrofolic acid) to become 5-methyltetrahydrofolic acid (5-MTHF).
5-MTHF gives the methyl group (the “M” part) to B12 so it can become MB12.  Unfortunately, many children have a defect in this enzyme.  In a recent study byDr. S. Jill James, 90% of children with ASD were found to have methylation defects.

*In my practice, 92% of children have benefited from MB12 treatment*


What are the benefits of MB12 treatment?

Enhancement in executive function:

  • Awareness
  • Cognition
  • Appropriateness
  • Eye contact
  • Responsiveness
  • Normalized behaviours and interaction


Promotion of speech and language

  • Spontaneous language
  • More complex sentences
  • Increased vocabulary


Improvements in socialization, understanding and expressing emotion

  • Initiation and interactive play
  • Understanding and feeling emotions
  • Affection and tolerance to touch


Side effects to MB12 treatment are not uncommon and include:

  • Hyperactivity
  • Self Stimulating Behaviour
  • Increased mouthing of objects
  • Sleep disturbances – which can be managed with other treatments
  • Aggression, hitting and biting – caused by frustration due to increased awareness


*Side effects can be mild to severe and are considered transient which means they will pass as treatment progresses*


MB12 is a treatment, not a cure.  However, many children using MB12 combined with other biomedical and non-biomedical therapies make incredible developmental gains and in a small percentage of children, have had their ASD label removed.


Parents should understand that the maximum results from MB12 therapy occur over years, not months, not weeks. Initial results will be obvious within the first 3-5 week period of time; but MB12’s power is in continued use.


Why is MB12 most effective when injected into the bum?

According to Dr. Neubrander (www.drneubrander.com), “Only the subcutaneous injectable route of administration into the adipose tissue of the buttocks will produce the remarkable results parents want to see!”

All forms of administration work to some degree, and some better than others. Injection has been shown to be, by far, the most effective route of administration.  It is through injection that the most dramatic strides in development are seen.

MB12 injection into the buttocks area allows MB12 to surround the cells and stay in the system continually.  Oral, transdermal or intranasal forms cause the MB12 levels to fluctuate up and down.

All cobalamins are absorbed in the last portion of the small intestine, the terminal ileum. Dr. Wakefield and Dr. Krigsman and Dr. Buie have shown through their research that an extremely high percentage of children on the autistic spectrum have an inflammatory bowel condition that affects this region of the intestinal tract. This makes injection a better choice than depending on the digestive tract for absorption.


Why is it important to fill out the Parent Designed Report Form?

From 136 possible responses, approximately 50% of parents report more than 28 positive or positive-negative responses while the remaining 50% of parents report fewer than 28 responses.

Children scoring greater than 28 responses have an excellent long-term prognosis , while children scoring fewer than 28 responses may have a good prognosis , though the prognosis is guarded and only accurately evaluated after adequate time has elapsed to compare those children’s progress to their peers.


It is the number of responses that is important, not the intensity of response.

About Natural Care Clinic

The Natural Care Clinic is a located on Appleby Line in Burlington. We specialize in naturopathy and massage therapy.

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